The Scuola Grande di San Rocco is a Venetian Renaissance building located in the San Polo district of Venice, Italy. The building was designed by architect Bartolomeo Bon and constructed between 1515 and 1560, with the interior frescoes being painted by Tintoretto between 1564 and 1588.

The Scuola was one of several charitable organizations in Venice that were dedicated to caring for the sick and the poor. Its full name is the Scuola di San Rocco, named after Saint Roch, a patron saint of plague victims. The building's ornate façade is decorated with sculptures and reliefs, including the coat of arms of the Scuola.

The interior of the Scuola is adorned with more than 60 large-scale paintings by Tintoretto, one of the greatest Venetian painters of the Renaissance. The paintings depict scenes from the life of Christ and the Virgin Mary, as well as from the Old Testament. The paintings are considered to be among the artist's most important works and are notable for their dramatic lighting, complex composition, and innovative use of color.

The Scuola also contains a number of other works of art, including paintings by Bellini and Titian, and a collection of reliquaries and other sacred objects. The building is open to the public and is a popular attraction for tourists visiting Venice.