Duomo di Genova, also known as the Cathedral of St. Lawrence, is the main cathedral of Genoa, Italy. It is located in the city center, near the Piazza Matteotti, and was first built in the 5th century, although it has undergone many changes and renovations since then.

The cathedral is a mix of Romanesque and Gothic styles, with a stunning black-and-white striped façade made of slate and marble. The interior is richly decorated with frescoes, sculptures, and other works of art. The cathedral has a nave and two aisles, and its transept is adorned with mosaics depicting the life of St. Lawrence.

One of the most notable features of the Duomo di Genova is its treasury, which contains many valuable religious artifacts, including the Sacro Catino, a 12th-century green glass dish said to be the Holy Grail, and the Ashes of St. John the Baptist, brought to Genoa by the Crusaders in the 12th century.

The cathedral also houses the Museo del Tesoro del Duomo, which contains many of the cathedral's most valuable artworks and artifacts, including the Holy Grail and the Ashes of St. John the Baptist, as well as a number of medieval illuminated manuscripts and other religious objects.

The Duomo di Genova is one of the most important and beloved landmarks of the city, and is a popular tourist attraction for visitors to the region.