Casa di Cristoforo Colombo, also known as the Christopher Columbus House, is a museum located in Genoa, Italy. The museum is housed in a building that was purportedly the birthplace of Christopher Columbus in 1451. However, this claim is contested, and there is no conclusive evidence that Columbus was actually born in this house.

The museum contains a collection of artifacts related to Columbus and his voyages, including maps, navigational instruments, and replicas of the ships he sailed. There are also exhibits about life in Genoa during Columbus's time, including information about the city's maritime history and the role of the Genoese in the Age of Exploration.

The museum is open to visitors year-round, and guided tours are available. In addition to its historical significance, the Casa di Cristoforo Colombo is also notable for its architecture. The building dates back to the 15th century and features a mixture of Renaissance and Gothic styles, with elaborate carvings and decorative details throughout.