Palacio Barolo is a landmark building located in the San Nicolás neighborhood of Buenos Aires, Argentina. It was designed by Italian architect Mario Palanti in the early 20th century for Luis Barolo, an Italian immigrant who had made his fortune in Argentina.

Completed in 1923, the Palacio Barolo was once the tallest building in the city and is now considered one of the most iconic buildings in Buenos Aires. It was constructed in the eclectic architectural style, which combined elements of Gothic, Art Nouveau, and Art Deco design. The building's height of 100 meters is symbolic, representing the number of cantos in Dante's Divine Comedy, and its 22 floors are divided into three parts representing Hell, Purgatory, and Heaven.

Palacio Barolo now serves as an office building, and there are guided tours of the building's interior and rooftop terrace, which offers panoramic views of Buenos Aires. The building also contains a museum, the "Salon de los Pasos Perdidos," which showcases the building's history and architecture. In addition, the building is often used for cultural events and concerts.