Shaikh Isa bin Ali House, also known as the Shaikh Isa bin Ali Al Khalifa House, is a historic house located in Muharraq, Bahrain. The house was built in the 1800s and belonged to Shaikh Isa bin Ali Al Khalifa, the former ruler of Bahrain. It is considered a significant cultural and architectural landmark in Bahrain.

The house has a traditional Bahraini architectural style, with a large courtyard in the center and rooms surrounding it. It is built using locally sourced materials such as coral stone, sea shells, and palm tree trunks. The walls are decorated with intricate patterns, and the ceilings are made of wood and adorned with Islamic calligraphy.

Today, the house has been converted into a museum that showcases the life and culture of the people of Bahrain during the 19th and early 20th centuries. Visitors can see traditional furniture, household items, and clothing that were used by the people during that time. The museum also features exhibits on the history of Muharraq and the impact of pearl diving on the island's economy.

In addition to its historical and cultural significance, the Shaikh Isa bin Ali House is also known for its role in Bahrain's political history. It was the site of an important meeting in 1926 between the leaders of Bahrain's opposition movement and British officials, where they discussed the future of the country's governance.