Santuario de Nossa Senhora do Cabo Espichel, also known as the Sanctuary of Our Lady of Cape Espichel, is a religious site located on the Cape Espichel in the municipality of Sesimbra, Portugal. It is a place of great religious significance and a popular destination for visitors, both for its natural beauty and its cultural and historical importance.

The sanctuary has been a place of pilgrimage since the 14th century and is dedicated to Our Lady of Cape Espichel, the patron saint of fishermen. The main chapel, which was built in the 18th century, is an imposing building with a neoclassical facade and a grandiose interior. The chapel is adorned with various statues and religious artifacts, including an image of Our Lady of Cape Espichel, which is believed to have miraculous powers.

In addition to the chapel, the sanctuary also includes a number of other religious buildings, including a hermitage and a convent. The site is also home to a lighthouse and a range of other historic buildings, including an ancient aqueduct, which was used to supply water to the site.